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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
TQ0185 | 14-Deoxy-11,12-didehydroandrographolide | AP10,14-dehydro Andrographolide | NF-κB |
14-Deoxy-11,12-didehydroandrographolide (AP10) has hypotensive, anti-inflammatory, anti-asthma, and anti-cancer actions. It can inhibit NF-κB activation. | |||
T23027 | MRT-10 | Hedgehog/Smoothened | |
MRT-10 is a Smoothened (Smo) receptor antagonist. | |||
T8425 | Linoleoyl Ethanolamide | TRP/TRPV Channel | |
Linoleoyl Ethanolamide is an endocannabinoid agent. It acts by binding to TRPV1 increasing ERK phosphorylation and AP-1 dependent transcription in CB-receptor in an independent manner. | |||
T4567 | Sulfaphenazole | Plisulfan,Raziosulfa,Depocid,Depotsulfonamide | P450 , Antibacterial |
Sulfaphenazole (Plisulfan) is an inhibitor of CYP2C9 (Ki: 0.3 μM) that demonstrates at least 100-fold selectivity over other CYP450 isoforms (Ki: 63/29 μM for CYP2C8/CYP2C18, respectively, and no activity at CYP1A1, CYP1... | |||
T25573 | Ketomethylenebestatin | ||
Ketomethylenebestatin is a carba-analog of bestatin,the aminopeptidase (AP) inhibitor. Ketomethylenebestatin is 10 fold less effective as an inhibitor of aminopeptidases than bestatin. | |||
T83856 | AP-1 | ||
AP-1, a miniaturized proteolysis-targeting chimera (PROTAC) incorporating an anaplastic lymphoma kinase (ALK) ligand connected to (±)-thalidomide via an ultrashort linker, effectively degrades ALK fusion proteins such as... | |||
TN5639 | Rocaglaol | Ferrugin,Aglaiastatin A | |
Rocaglaol is a potent anticancer drug that induces apoptosis of LNCaP cells through the mitochondrial pathway and its G2/M-phase cell cycle arrest is associated with the down-regulation of Cdc25C and the dephosphorylatio... | |||
T70063 | GYKI 52466 HCl | ||
GYKI 52466 is an allosteric AMPA receptor antagonist. It selectively inhibits AMPA-induced inward currents (IC50 = 7.5 µM) over NMDA- or GABA-induced inward currents in primary rat hippocampal neurons at 50 µM but also i... |